1. Prepare the Glasses:
Rub a lime slice around the rim of each glass. Dip the rims in salt or sugar (whichever you prefer) to coat. Set aside.
2. Blend the Watermelon:
In a blender, puree the watermelon cubes until smooth. Strain through a fine - mesh sieve to remove any pulp, if desired.
3. Mix the Margarita:
In a cocktail shaker, combine the watermelon juice, tequila, lime juice, orange liqueur, simple syrup and a handful of ice cubes. Shake well until mixture is well chilled.
4. Serve:
Fill the prepared glasses with ice cubes. Strain the margarita mixture into the glasses, leaving the ice from the shaker behind.
Garnish with lime slices and watermelon wedges.
Serve immediately and enjoy.